The Need

In the realm of medical diagnostics, the need for precise and non-invasive detection of molecular-level pathology has been a longstanding challenge. Traditional imaging techniques often fall short in providing detailed insights into biological processes at this scale. To address this gap, there is a critical demand for advanced biochemically responsive magnetic resonance imaging (MRI) probes that can offer unparalleled accuracy in detecting, quantifying, and mapping pathology at the molecular level.

The Technology

Introducing a groundbreaking solution, our technology leverages stable iron complexes that dynamically switch between high-spin monomeric and antiferromagnetically coupled dimeric species within the pH range encountered within human pathophysiology. This innovation enables a significant change in the relaxivity of the probe, providing a robust and biochemically responsive MR imaging agent. The iron complexes ensure a clear "off/on" effect, where the antiferromagnetic species exhibits low relaxivity, and the monomeric complex boasts high relaxivity, overcoming the limitations of traditional Gd-based probes.

Commercial Applications

• In Vivo Imaging of Tumors: Precise and detailed imaging of solid tumors for accurate diagnosis and treatment planning.
• Blood Clot Detection: Rapid and sensitive identification of blood clots, crucial for managing thrombotic conditions.
• Brain Lesion Imaging: High-resolution imaging of brain lesions for improved understanding and treatment of neurological disorders.
• pH Level Aberration Detection: Identification of regions with aberrant pH levels, offering insights into various physiological conditions.
• Blood-Brain-Barrier Integrity Assessment: Accurate assessment of blood-brain-barrier integrity, vital for understanding neurological diseases and drug delivery.

Benefits/Advantages

• Enhanced Sensitivity: Our technology provides superior sensitivity, ensuring reliable detection even at low concentrations.
• Dynamic Relaxivity Control: The ability to modulate relaxivity in response to biochemical stimuli ensures a wide dynamic range for accurate imaging.
• Multi-Application Capabilities: From tumor growth rate determination to arterial stenosis detection, the technology's versatility caters to diverse medical imaging needs.
• Non-Invasive Diagnosis: Offering a non-invasive approach to imaging, our technology minimizes patient discomfort and risks associated with traditional invasive methods.
• Clear "Off/On" Imaging: The distinct relaxivity states of our iron complexes facilitate a clear and reliable "off/on" imaging effect, enhancing diagnostic precision.

In summary, our biochemically responsive MR imaging probes represent a paradigm shift in medical diagnostics, providing a versatile and sensitive tool for clinicians and researchers alike. With applications ranging from cancer detection to neurological imaging, our technology is poised to revolutionize the landscape of molecular-level pathology visualization.