The Need

Endothelial injury is a significant pathological mechanism underlying various neurological disorders, including neurodegenerative, neuroinflammatory, and cerebrovascular diseases. Current clinical and research settings lack reliable biomarkers to detect or measure endothelial injury in the human CNS. Given the crucial role of endothelial cells in maintaining brain health and function, there is an urgent need for novel markers that can indicate endothelial injury or loss of integrity in the CNS.

The Technology

This innovative technology involves methods to detect endothelial injury in a subject by measuring elevated levels of specific endothelial markers such as syndecan-1, syndecan-4, thrombomodulin, plasmalemmal vesicle-associated protein, E-selectin, and VE-cadherin. By detecting two or more of these markers, the technology enables targeted treatment for neurodegenerative disorders, neuroinflammatory conditions, and cerebrovascular diseases. It also allows for monitoring treatment effects and adjusting therapeutic strategies based on the progression of endothelial injury.

Commercial Applications

• Diagnosis of Neurodegenerative Disorders: Detecting endothelial injury markers to diagnose conditions like Alzheimer’s disease, Parkinson’s disease, and vascular dementia.
• Treatment of Neuroinflammatory Conditions: Identifying elevated endothelial markers to tailor treatments for multiple sclerosis, neuromyelitis optica, and similar diseases.
• Cerebrovascular Disease Management: Using marker levels to manage and treat conditions such as ischemic or hemorrhagic strokes and hypertensive encephalopathy.
• Traumatic Brain and Spinal Cord Injury Care: Monitoring endothelial injury markers to optimize treatments for acute and chronic sequelae of traumatic brain or spinal cord injuries.
• Chemotherapy and Radiation Monitoring: Assessing the impact of cancer treatments on the brain and adjusting therapeutic approaches accordingly.

Benefits/Advantages

• Early Detection: Provides a reliable method for early detection of endothelial injury in the CNS, facilitating timely intervention.
• Personalized Treatment: Enables the customization of treatment plans based on specific endothelial injury markers, improving patient outcomes.
• Comprehensive Monitoring: Allows for continuous monitoring of disease progression and treatment efficacy, ensuring optimal care.
• Broad Applicability: Useful across various neurological and systemic disorders, enhancing its relevance in diverse clinical scenarios.
• Enhanced Research Capabilities: Provides a valuable tool for research into the pathogenesis of neurological disorders and the development of new therapies.